› 4u0f

X-ray diffraction
2.22Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein p24 Chain: A
Molecule details ›
Chain: A
Length: 231 amino acids
Theoretical weight: 25.46 KDa
Source organism: Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12493 (Residues: 133-363; Coverage: 46%)
Gene name: gag
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand EDO 1 x EDO
Ligand 3A8 1 x 3A8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: P6
Unit cell:
a: 90.88Å b: 90.88Å c: 56.58Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.243 0.242 0.27
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

49 review citations

HIV-1 assembly, release and maturation.
Freed EO. (2015)
48 more

2 mentions without citation

Rotten to the core: antivirals targeting the HIV-1 capsid core.
McFadden et al. (2021)
1 more