› 4u4f

X-ray diffraction
4.79Å resolution

Structure of GluA2* in complex with partial agonist (S)-5-Nitrowillardiine

Released:
DOI: 10.2210/pdb4u4f/pdb
PDB entry 4u4f coloured by chain, front view.
PDB entry 4u4f coloured by chain, side view.
PDB entry 4u4f coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structure of an agonist-bound ionotropic glutamate receptor.
Yelshanskaya MV, Li M, Sobolevsky AI
Science 345 1070-4 (2014)
PMID: 25103407

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148611 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Glutamate receptor 2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 822 amino acids
Theoretical weight: 92.24 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P19491 (Residues: 25-847; Coverage: 95%)
  • Best match: P19491-2 (Residues: 25-847)
Gene names: GluA2, Glur2, Gria2
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NWD 4 x NWD
Ligand NAG 1 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: C2221
Unit cell:
a: 141.374Å b: 166.575Å c: 566.604Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.229 0.228 0.262
Expression system: Spodoptera frugiperda

Quick links

Citations

16 review citations

Structural and Functional Architecture of AMPA-Type Glutamate Receptors and Their Auxiliary Proteins.
Greger et al. (2017)
15 more

11 mentions without citation

Emerging structural insights into the function of ionotropic glutamate receptors.
Karakas et al. (2015)
10 more