› 4wa2

X-ray diffraction
2.5Å resolution

The crystal structure of hemagglutinin from a H3N8 influenza virus isolated from New England harbor seals in complex with 3'SLN

Released:
DOI: 10.2210/pdb4wa2/pdb
Model geometry
Fit model/data
PDB entry 4wa2 coloured by chain, front view.
PDB entry 4wa2 coloured by chain, side view.
PDB entry 4wa2 coloured by chain, top view.
Source organism: Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))
Primary publication:
Structural and functional analysis of surface proteins from an A(H3N8) influenza virus isolated from New England harbor seals.
Yang H, Nguyen HT, Carney PJ, Guo Z, Chang JC, Jones J, Davis CT, Villanueva JM, Gubareva LV, Stevens J
J Virol 89 2801-12 (2015)
PMID: 25540377

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125140 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Hemagglutinin Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 496 amino acids
Theoretical weight: 55.66 KDa
Source organism: Influenza A virus (A/harbor seal/Massachusetts/1/2011(H3N8))
Expression system: Trichoplusia ni
UniProt:
  • Canonical: I6NNE1 (Residues: 24-519; Coverage: 88%)
Gene name: HA
Sequence domains: Haemagglutinin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, GAL, SIA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
1 bound ligand:
Ligand NAG 8 x NAG
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P1
Unit cell:
a: 79.541Å b: 102.327Å c: 109.666Å
α: 90.02° β: 90.02° γ: 89.51°
R-values:
R R work R free
0.187 0.184 0.236
Expression system: Trichoplusia ni

Quick links

Citations

2 review citations

Biosensor-based epitope mapping of antibodies targeting the hemagglutinin and neuraminidase of influenza A virus.
Guo et al. (2018)
1 more

3 mentions without citation

New insights into influenza A specificity: an evolution of paradigms.
Ji et al. (2017)
2 more