› 4wzu

X-ray diffraction
1.88Å resolution

Crystal structure of beta-ketoacyl-(acyl carrier protein) synthase III-2 (FabH2) from Vibrio cholerae

Released:
DOI: 10.2210/pdb4wzu/pdb
PDB entry 4wzu coloured by chain, front view.
PDB entry 4wzu coloured by chain, side view.
PDB entry 4wzu coloured by chain, top view.
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Entry authors: Hou J, Chruszcz M, Zheng H, Cooper DR, Chordia MD, Zimmerman MD, Anderson WF, Minor W, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
Acetyl-CoA + malonyl-[acyl-carrier-protein] = acetoacetyl-[acyl-carrier-protein] + CoA + CO(2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-575695 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-ketoacyl-[acyl-carrier-protein] synthase III 2 Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 39.07 KDa
Source organism: Vibrio cholerae O1 biovar El Tor str. N16961
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9KLJ3 (Residues: 1-362; Coverage: 100%)
Gene names: VC_A0751, fabH2
Sequence domains:
Structure domains: Peroxisomal Thiolase; Chain A, domain 1

Ligands and Environments

1 bound ligand:
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21212
Unit cell:
a: 78.858Å b: 60.212Å c: 68.436Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.202
Expression system: Escherichia coli

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