› 4x3x

X-ray diffraction
2Å resolution

The crystal structure of Arc C-lobe

Released:
DOI: 10.2210/pdb4x3x/pdb
PDB entry 4x3x coloured by chain, front view.
PDB entry 4x3x coloured by chain, side view.
PDB entry 4x3x coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Structural basis of arc binding to synaptic proteins: implications for cognitive disease.
Zhang W, Wu J, Ward MD, Yang S, Chuang YA, Xiao M, Li R, Leahy DJ, Worley PF
Neuron 86 490-500 (2015)
PMID: 25864631

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178994 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Activity-regulated cytoskeleton-associated protein Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.62 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63053 (Residues: 277-362; Coverage: 22%)
Gene name: Arc
Sequence domains: Arc C-lobe

Ligands and Environments

No bound ligands
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: C2221
Unit cell:
a: 59.067Å b: 74.659Å c: 38.292Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.218 0.217 0.23
Expression system: Escherichia coli

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Citations

28 review citations

Role of Immediate-Early Genes in Synaptic Plasticity and Neuronal Ensembles Underlying the Memory Trace.
Minatohara et al. (2015)
27 more

7 mentions without citation

Structural basis of arc binding to synaptic proteins: implications for cognitive disease.
Zhang et al. (2015)
6 more