› 4xnv

X-ray diffraction
2.2Å resolution

The human P2Y1 receptor in complex with BPTU

Released:
DOI: 10.2210/pdb4xnv/pdb
PDB entry 4xnv coloured by chain, front view.
PDB entry 4xnv coloured by chain, side view.
PDB entry 4xnv coloured by chain, top view.
Source organisms:
Primary publication:
Two disparate ligand-binding sites in the human P2Y1 receptor.
Zhang D, Gao ZG, Zhang K, Kiselev E, Crane S, Wang J, Paoletta S, Yi C, Ma L, Zhang W, Han GW, Liu H, Cherezov V, Katritch V, Jiang H, Stevens RC, Jacobson KA, Zhao Q, Wu B
Nature 520 317-21 (2015)
PMID: 25822790

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132355 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P2Y purinoceptor 1; Rubredoxin Chain: A
Molecule details ›
Chain: A
Length: 421 amino acids
Theoretical weight: 47.47 KDa
Source organisms: Expression system: Spodoptera
UniProt:
  • Canonical: P47900 (Residues: 2-247, 253-373; Coverage: 98%)
  • Canonical: P00268 (Residues: 1-54; Coverage: 100%)
Gene name: P2RY1
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand BUR 1 x BUR
Ligand CLR 1 x CLR
Ligand Y01 3 x Y01
Ligand OLC 8 x OLC
Ligand 1PE 1 x 1PE
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: R3
Unit cell:
a: 66.27Å b: 66.27Å c: 239.07Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.207 0.23
Expression system: Spodoptera

Quick links

Citations

60 review citations

How Ligands Illuminate GPCR Molecular Pharmacology.
Wacker et al. (2017)
59 more

64 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
63 more