› 4y0i

X-ray diffraction
1.66Å resolution

GABA-aminotransferase inactivated by conformationally-restricted inactivator

Released:
DOI: 10.2210/pdb4y0i/pdb
PDB entry 4y0i coloured by chain, front view.
PDB entry 4y0i coloured by chain, side view.
PDB entry 4y0i coloured by chain, top view.
Source organism: Sus scrofa
Entry authors: Wu R, Sanishvili R, Lee HV, Dustin DH, Emma D, Neil K, Silverman RB, Liu D

Function and Biology Details

Reactions catalysed: 
4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate
(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3-oxopropanoate + L-glutamate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160351 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
4-aminobutyrate aminotransferase, mitochondrial Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 461 amino acids
Theoretical weight: 52.24 KDa
Source organism: Sus scrofa
Expression system: Sus barbatus
UniProt:
  • Canonical: P80147 (Residues: 39-499; Coverage: 92%)
Gene names: ABAT, GABAT
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand PSZ 4 x PSZ
Ligand FES 2 x FES
Ligand GOL 2 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-B
Spacegroup: P21
Unit cell:
a: 69.483Å b: 226.755Å c: 71.425Å
α: 90° β: 108.79° γ: 90°
R-values:
R R work R free
0.173 0.172 0.204
Expression system: Sus barbatus

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