› 4yol

X-ray diffraction
1.97Å resolution

Human fibroblast growth factor-1 C16S/A66C/C117A/P134A

Released:
DOI: 10.2210/pdb4yol/pdb
PDB entry 4yol coloured by chain, front view.
PDB entry 4yol coloured by chain, side view.
PDB entry 4yol coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
Xia X, Kumru OS, Blaber SI, Middaugh CR, Li L, Ornitz DM, Sutherland MA, Tenorio CA, Blaber M
J Pharm Sci 105 1444-53 (2016)
PMID: 27019961

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138603 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 147 amino acids
Theoretical weight: 16.78 KDa
Source organism: Homo sapiens
Expression system: Atlantibacter hermannii
UniProt:
  • Canonical: P05230 (Residues: 16-155; Coverage: 90%)
  • Best match: P05230-2 (Residues: 16-56)
Gene names: FGF1, FGFA
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

2 bound ligands:
Ligand FLC 2 x FLC
Ligand IMD 1 x IMD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: C2221
Unit cell:
a: 75.63Å b: 97.831Å c: 107.914Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.16 0.199
Expression system: Atlantibacter hermannii

Quick links

Citations

2 review citations

Unraveling the Connection between Fibroblast Growth Factor and Bone Morphogenetic Protein Signaling.
Schliermann et al. (2018)
1 more

1 mention without citation

Engineering a Cysteine-Free Form of Human Fibroblast Growth Factor-1 for "Second Generation" Therapeutic Application.
Xia et al. (2016)