› 4yp1

X-ray diffraction
2.65Å resolution

Misting with CDA

Released:
DOI: 10.2210/pdb4yp1/pdb
PDB entry 4yp1 coloured by chain, front view.
PDB entry 4yp1 coloured by chain, side view.
PDB entry 4yp1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural Insights into the Distinct Binding Mode of Cyclic Di-AMP with SaCpaA_RCK.
Chin KH, Liang JM, Yang JG, Shih MS, Tu ZL, Wang YC, Sun XH, Hu NJ, Liang ZX, Dow JM, Ryan RP, Chou SH
Biochemistry 54 4936-51 (2015)
PMID: 26171638

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-174810 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Stimulator of interferon genes protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 210 amino acids
Theoretical weight: 23.86 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q3TBT3 (Residues: 138-344; Coverage: 55%)
Gene names: Eris, Mita, Mpys, Sting, Sting1, Tmem173
Sequence domains: Transmembrane protein 173
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand 2BA 1 x 2BA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL13B1
Unit cell:
a: 45.427Å b: 48.208Å c: 172.42Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.21 0.21 0.26
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Cyclic di-GMP: second messenger extraordinaire.
Jenal et al. (2017)
12 more

3 mentions without citation

Cyclic di-AMP, a second messenger of primary importance: tertiary structures and binding mechanisms.
He et al. (2020)
2 more