› 4zy3

X-ray diffraction
1.8Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195563 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kelch-like ECH-associated protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 311 amino acids
Theoretical weight: 34.27 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9Z2X8 (Residues: 321-609; Coverage: 46%)
Gene names: Inrf2, Keap1, Kiaa0132
Sequence domains: Kelch motif
Structure domains: Kelch-type beta propeller

Ligands and Environments

2 bound ligands:
Ligand FMT 2 x FMT
Ligand K67 2 x K67
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C2
Unit cell:
a: 126.399Å b: 75.193Å c: 109.797Å
α: 90° β: 105.35° γ: 90°
R-values:
R R work R free
0.191 0.19 0.212
Expression system: Escherichia coli

Quick links

Citations

81 review citations

NRF2 and the Hallmarks of Cancer.
Rojo de la Vega et al. (2018)
80 more

16 mentions without citation

Design and development of Nrf2 modulators for cancer chemoprevention and therapy: a review.
Sova et al. (2018)
15 more