› 5a3r

X-ray diffraction
3.05Å resolution

Crystal structure of the (SR) Calcium ATPase E2.BeF3- complex bound to TNP-AMPPCP

Released:
DOI: 10.2210/pdb5a3r/pdb
PDB entry 5a3r coloured by chain, front view.
PDB entry 5a3r coloured by chain, side view.
PDB entry 5a3r coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Crystal Structure of the Vanadate-Inhibited Ca(2+)-ATPase.
Clausen JD, Bublitz M, Arnou B, Olesen C, Andersen JP, Møller JV, Nissen P
Structure 24 617-623 (2016)
PMID: 27050689

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chain: A
Molecule details ›
Chain: A
Length: 994 amino acids
Theoretical weight: 109.67 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
  • Best match: P04191-2 (Residues: 1-994)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand DL5 1 x DL5
Ligand K 1 x K
Ligand MG 3 x MG
1 modified residue:
Ligand BFD 1 x BFD

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P212121
Unit cell:
a: 57.53Å b: 114.967Å c: 227.699Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.214 0.257

Quick links

Citations

4 review citations

Primary Active Ca2+ Transport Systems in Health and Disease.
Chen et al. (2020)
3 more

2 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
1 more