› 5caz

X-ray diffraction
1.8Å resolution

Crystallographic structure of apo human rotavirus K8 VP8*

Released:
DOI: 10.2210/pdb5caz/pdb
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PDB entry 5caz coloured by chain, front view.
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PDB entry 5caz coloured by chain, top view.
Source organism: Rotavirus A K8/G1
Primary publication:
Substantial Receptor-induced Structural Rearrangement of Rotavirus VP8*: Potential Implications for Cross-Species Infection.
Yu X, Mishra R, Holloway G, von Itzstein M, Coulson BS, Blanchard H
Chembiochem 16 2176-81 (2015)
PMID: 26250751

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Outer capsid protein VP8* Chain: A
Molecule details ›
Chain: A
Length: 161 amino acids
Theoretical weight: 18.38 KDa
Source organism: Rotavirus A K8/G1
Expression system: Escherichia coli
UniProt:
  • Canonical: Q01641 (Residues: 64-224; Coverage: 21%)
Sequence domains: Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain
Structure domains: Jelly Rolls

Ligands and Environments

3 bound ligands:
Ligand IPA 7 x IPA
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P65
Unit cell:
a: 62.81Å b: 62.81Å c: 74.64Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.175 0.173 0.216
Expression system: Escherichia coli

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Citations

1 review citation

Histo-blood group antigens as mediators of infections.
Heggelund et al. (2017)
1 other article

3 mentions without citation

Structural Basis of Glycan Recognition of Rotavirus.
Sun et al. (2021)
2 more

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