› 5cni

X-ray diffraction
2.69Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171999 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Metabotropic glutamate receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 503 amino acids
Theoretical weight: 55.71 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q14416 (Residues: 2-493; Coverage: 56%)
Gene names: GPRC1B, GRM2, MGLUR2
Sequence domains: Receptor family ligand binding region
Structure domains: Rossmann fold

Ligands and Environments

4 bound ligands:
Ligand GLU 2 x GLU
Ligand CL 2 x CL
Ligand NA 2 x NA
Ligand NAG 4 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 31-ID
Spacegroup: P21212
Unit cell:
a: 156.079Å b: 79.332Å c: 93.603Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.17 0.168 0.222
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

Molecular insights into allosteric modulation of Class C G protein-coupled receptors.
Leach et al. (2017)
1 more

6 mentions without citation

Evaluation of Sweetener Synergy in Humans by Isobole Analyses.
Reyes et al. (2019)
5 more