› 5d4q

X-ray diffraction
2.39Å resolution

Crystal structure of GASDALIE IgG1 Fc

Released:
DOI: 10.2210/pdb5d4q/pdb
PDB entry 5d4q coloured by chain, front view.
PDB entry 5d4q coloured by chain, side view.
PDB entry 5d4q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa.
Ahmed AA, Keremane SR, Vielmetter J, Bjorkman PJ
J Struct Biol 194 78-89 (2016)
PMID: 26850169

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134849 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Immunoglobulin heavy constant gamma 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 221 amino acids
Theoretical weight: 24.97 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P01857 (Residues: 109-328; Coverage: 55%)
  • Best match: P01857-1 (Residues: 109-329)
Gene name: IGHG1
Sequence domains: Immunoglobulin C1-set domain
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL
Carbohydrate polymer
1 bound ligand:
Ligand FUC 1 x FUC
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 49.32Å b: 79.13Å c: 137.62Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.243 0.241 0.258
Expression system: Homo sapiens

Quick links

Citations

16 review citations

Conceptual Approaches to Modulating Antibody Effector Functions and Circulation Half-Life.
Saunders KO. (2019)
15 more

1 mention without citation

Structural characterization of GASDALIE Fc bound to the activating Fc receptor FcγRIIIa.
Ahmed et al. (2016)