› 5d7y

X-ray diffraction
3.89Å resolution

Crystal structure of Hepatitis B virus T=4 capsid in complex with the allosteric modulator HAP18

Released:
DOI: 10.2210/pdb5d7y/pdb
PDB entry 5d7y coloured by chain, front view.
PDB entry 5d7y coloured by chain, side view.
PDB entry 5d7y coloured by chain, top view.
Source organism: Hepatitis B virus subtype adyw
Primary publication:
Hepatitis B Virus Capsids Have Diverse Structural Responses to Small-Molecule Ligands Bound to the Heteroaryldihydropyrimidine Pocket.
Venkatakrishnan B, Katen SP, Francis S, Chirapu S, Finn MG, Zlotnick A
J Virol 90 3994-4004 (2016)
PMID: 26842475

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 240-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 150 amino acids
Theoretical weight: 16.82 KDa
Source organism: Hepatitis B virus subtype adyw
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P03147 (Residues: 1-149; Coverage: 81%)
Gene name: C
Sequence domains: Hepatitis core antigen
Structure domains: Viral capsid, core domain supefamily, Hepatitis B virus

Ligands and Environments

1 bound ligand:
Ligand 58H 2 x 58H
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: C2
Unit cell:
a: 529.375Å b: 367.411Å c: 542.002Å
α: 90° β: 104.79° γ: 90°
R-values:
R R work R free
0.263 0.263 0.273
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

The Structural Biology of Hepatitis B Virus: Form and Function.
Venkatakrishnan et al. (2016)
7 more

6 mentions without citation

Targeting the multifunctional HBV core protein as a potential cure for chronic hepatitis B.
Viswanathan et al. (2020)
5 more