› 5dj9

X-ray diffraction
1.55Å resolution

Crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49 in a complex with gabaculine

Released:
DOI: 10.2210/pdb5dj9/pdb
PDB entry 5dj9 coloured by chain, front view.
PDB entry 5dj9 coloured by chain, side view.
PDB entry 5dj9 coloured by chain, top view.
Source organism: Toxoplasma gondii ME49
Entry authors: Filippova EV, Minasov G, Flores K, Le HV, Silverman RB, McLeod RL, Anderson WF, Center for Structural Genomics of Infectious Diseases (CSGID)

Function and Biology Details

Reaction catalysed: 
L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197464 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ornithine aminotransferase Chains: A, B
Molecule details ›
Chains: A, B
Length: 441 amino acids
Theoretical weight: 48.39 KDa
Source organism: Toxoplasma gondii ME49
Expression system: Escherichia coli
UniProt:
  • Canonical: S8EY38 (Residues: 1-441; Coverage: 100%)
Gene name: TGME49_269110
Sequence domains: Aminotransferase class-III
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand SO4 8 x SO4
Ligand BTB 1 x BTB
Ligand PXG 2 x PXG
Ligand TRS 2 x TRS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P1
Unit cell:
a: 56.258Å b: 60.887Å c: 63.499Å
α: 100.83° β: 92.38° γ: 107.86°
R-values:
R R work R free
0.16 0.158 0.19
Expression system: Escherichia coli

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