› 5gu6

X-ray diffraction
2Å resolution

Crystal structure of Human ERp44 form I

Released:
DOI: 10.2210/pdb5gu6/pdb
PDB entry 5gu6 coloured by chain, front view.
PDB entry 5gu6 coloured by chain, side view.
PDB entry 5gu6 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.
Watanabe S, Harayama M, Kanemura S, Sitia R, Inaba K
Proc Natl Acad Sci U S A 114 E3224-E3232 (2017)
PMID: 28373561

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-189699 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Endoplasmic reticulum resident protein 44 Chain: A
Molecule details ›
Chain: A
Length: 379 amino acids
Theoretical weight: 43.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9BS26 (Residues: 30-402; Coverage: 99%)
Gene names: ERP44, KIAA0573, TXNDC4, UNQ532/PRO1075
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: P3121
Unit cell:
a: 81.63Å b: 81.63Å c: 139.91Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.206 0.204 0.24
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Chemistry and Enzymology of Disulfide Cross-Linking in Proteins.
Fass et al. (2018)
3 more

2 mentions without citation

Structural basis of pH-dependent client binding by ERp44, a key regulator of protein secretion at the ER-Golgi interface.
Watanabe et al. (2017)
1 more