› 5i1e

X-ray diffraction
2.7Å resolution

CRYSTAL STRUCTURE OF HUMAN GERMLINE ANTIBODY IGHV3-53/IGKV1-39

Released:
DOI: 10.2210/pdb5i1e/pdb
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PDB entry 5i1e coloured by chain, front view.
PDB entry 5i1e coloured by chain, side view.
PDB entry 5i1e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural diversity in a human antibody germline library.
Teplyakov A, Obmolova G, Malia TJ, Luo J, Muzammil S, Sweet R, Almagro JC, Gilliland GL
OpenAccess logo MAbs 8 1045-63
PMID: 27210805

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-213773 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
FAB LIGHT CHAIN Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.3 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins
FAB HEAVY CHAIN Chain: H
Molecule details ›
Chain: H
Length: 227 amino acids
Theoretical weight: 24.24 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Structure domains: Immunoglobulins

Ligands and Environments

2 bound ligands:
Ligand SO4 1 x SO4
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P6522
Unit cell:
a: 89.38Å b: 89.38Å c: 212.38Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.195 0.191 0.264
Expression system: Homo sapiens

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Citations

9 review citations

Antibody Structure and Function: The Basis for Engineering Therapeutics.
Chiu et al. (2019)
8 more

9 mentions without citation

Impact of the Protein Data Bank on antineoplastic approvals.
Westbrook et al. (2020)
8 more

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