› 5ic1

X-ray diffraction
2.2Å resolution

Structural analysis of a talin triple domain module, E1794Y, E1797Y, Q1801Y mutant

Released:
DOI: 10.2210/pdb5ic1/pdb
PDB entry 5ic1 coloured by chain, front view.
PDB entry 5ic1 coloured by chain, side view.
PDB entry 5ic1 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural and Functional Analysis of a Talin Triple-Domain Module Suggests an Alternative Talin Autoinhibitory Configuration.
Zhang H, Chang YC, Huang Q, Brennan ML, Wu J
Structure 24 721-729 (2016)
PMID: 27150043

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150641 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Talin-1 Chain: A
Molecule details ›
Chain: A
Length: 469 amino acids
Theoretical weight: 49.41 KDa
Source organism: Mus musculus
Expression system: Escherichia coli
UniProt:
  • Canonical: P26039 (Residues: 1357-1822; Coverage: 18%)
Gene names: Tln, Tln1
Sequence domains: Talin 1-like, rod segment domain

Ligands and Environments

1 bound ligand:
Ligand EDO 3 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1
Spacegroup: P21
Unit cell:
a: 60.633Å b: 67.193Å c: 65.955Å
α: 90° β: 101.48° γ: 90°
R-values:
R R work R free
0.21 0.208 0.249
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Talin - the master of integrin adhesions.
Klapholz et al. (2017)
13 other articles

2 mentions without citation

The Architecture of Talin1 Reveals an Autoinhibition Mechanism.
Dedden et al. (2019)
1 more