› 5is8

X-ray diffraction
2.71Å resolution

Crystal structure of mouse CARM1 in complex with inhibitor SA0271

Released:
DOI: 10.2210/pdb5is8/pdb
PDB entry 5is8 coloured by chain, front view.
PDB entry 5is8 coloured by chain, side view.
PDB entry 5is8 coloured by chain, top view.
Source organism: Mus musculus
Entry authors: Cura V, Marechal N, Mailliot J, Troffer-Charlier N, Hassenboehler P, Wurtz JM, Bonnefond L, Cavarelli J

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N(omega)-methyl-L-arginine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194407 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-arginine methyltransferase CARM1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 381 amino acids
Theoretical weight: 43.11 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9WVG6 (Residues: 130-507; Coverage: 62%)
Gene names: Carm1, Prmt4
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand 6D1 3 x 6D1
Ligand EDO 3 x EDO
Ligand SAH 1 x SAH
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21212
Unit cell:
a: 74.544Å b: 98.623Å c: 207.467Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.194 0.242
Expression system: Spodoptera frugiperda

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