› 5kkc

X-ray diffraction
1.86Å resolution

l-lactate dehydrogenase from rabbit muscle with the inhibitor 6DHNAD

Released:
DOI: 10.2210/pdb5kkc/pdb
PDB entry 5kkc coloured by chain, front view.
PDB entry 5kkc coloured by chain, side view.
PDB entry 5kkc coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Ligand binding phenomena that pertain to the metabolic function of renalase.
Beaupre BA, Roman JV, Hoag MR, Meneely KM, Silvaggi NR, Lamb AL, Moran GR
Arch Biochem Biophys 612 46-56 (2016)
PMID: 27769837

Function and Biology Details

Reaction catalysed: 
(S)-lactate + NAD(+) = pyruvate + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146607 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
L-lactate dehydrogenase A chain Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 331 amino acids
Theoretical weight: 36.47 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P13491 (Residues: 2-332; Coverage: 100%)
Gene name: LDHA
Sequence domains:
Structure domains:

Ligands and Environments


Cofactor: Ligand 6V0 4 x 6V0
1 bound ligand:
Ligand SO4 5 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-2
Spacegroup: P21
Unit cell:
a: 63.602Å b: 126.085Å c: 84.237Å
α: 90° β: 99.94° γ: 90°
R-values:
R R work R free
0.17 0.17 0.211

Quick links

Citations

1 review citation

The enzyme: Renalase.
Moran et al. (2017)
6 other articles

1 mention without citation

Ligand binding phenomena that pertain to the metabolic function of renalase.
Beaupre et al. (2016)