› 5l7n

X-ray diffraction
2.2Å resolution

Plexin A1 extracellular fragment, domains 7-10 (IPT3-IPT6)

Released:
DOI: 10.2210/pdb5l7n/pdb
PDB entry 5l7n coloured by chain, front view.
PDB entry 5l7n coloured by chain, side view.
PDB entry 5l7n coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural Basis for Plexin Activation and Regulation.
Kong Y, Janssen BJ, Malinauskas T, Vangoor VR, Coles CH, Kaufmann R, Ni T, Gilbert RJ, Padilla-Parra S, Pasterkamp RJ, Jones EY
OpenAccess logo Neuron 91 548-60 (2016)
PMID: 27397516

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159712 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Plexin-A1 Chain: A
Molecule details ›
Chain: A
Length: 393 amino acids
Theoretical weight: 42.93 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: P70206 (Residues: 861-1241; Coverage: 20%)
Gene names: Kiaa4053, Plxna1
Sequence domains: IPT/TIG domain

Ligands and Environments

3 bound ligands:
Ligand NAG 3 x NAG
Ligand EDO 1 x EDO
Ligand PEG 1 x PEG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: C2221
Unit cell:
a: 75.88Å b: 82.51Å c: 125.6Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.232 0.23 0.27
Expression system: Homo sapiens

Quick links

Citations

14 review citations

TREM2-Ligand Interactions in Health and Disease.
Kober et al. (2017)
13 more