5t1m

X-ray diffraction
2.53Å resolution

Cetuximab Fab in complex with CQYDLSTRRLKC

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero trimer (preferred)
monomeric
PDBe Complex ID:
PDB-CPX-230979 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
CETUXIMAB FAB LIGHT CHAIN Chains: A, C
Molecule details ›
Chains: A, C
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Mus musculus
Expression system: unidentified
Structure domains: Immunoglobulins
CETUXIMAB FAB HEAVY CHAIN Chains: B, D
Molecule details ›
Chains: B, D
Length: 221 amino acids
Theoretical weight: 23.71 KDa
Source organism: Mus musculus
Expression system: unidentified
Structure domains: Immunoglobulins
CYCLIC PEPTIDE CQYDLSTRRLKC Chains: E, F, H
Molecule details ›
Chains: E, F, H
Length: 12 amino acids
Theoretical weight: 1.49 KDa
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments

2 bound ligands:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 64.2Å b: 82.5Å c: 212.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.156 0.153 0.216
Expression systems:
  • unidentified
  • Not provided