› 5tiz

X-ray diffraction
2.87Å resolution

Schistosoma japonicum (Blood Fluke) Sulfotransferase

Released:
DOI: 10.2210/pdb5tiz/pdb
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Source organism: Schistosoma japonicum
Primary publication:
Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
Taylor AB, Roberts KM, Cao X, Clark NE, Holloway SP, Donati E, Polcaro CM, Pica-Mattoccia L, Tarpley RS, McHardy SF, Cioli D, LoVerde PT, Fitzpatrick PF, Hart PJ
J Biol Chem 292 11154-11164 (2017)
PMID: 28536265

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-111146 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell wall integrity and stress response component 1 Chain: A
Molecule details ›
Chain: A
Length: 263 amino acids
Theoretical weight: 30.6 KDa
Source organism: Schistosoma japonicum
Expression system: Escherichia coli
UniProt:
  • Canonical: C1LER5 (Residues: 1-253; Coverage: 100%)
Sequence domains: Sulfotransferase domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

1 bound ligand:
Ligand A3P 1 x A3P
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 24-ID-E
Spacegroup: P4122
Unit cell:
a: 57.308Å b: 57.308Å c: 181.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.225 0.276
Expression system: Escherichia coli

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Citations

4 review citations

Schistosomiasis then and now: what has changed in the last 100 years?
Wilson RA. (2020)
3 more

3 mentions without citation

Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy.
Taylor et al. (2017)
2 more

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