› 5u1v

X-ray diffraction
3.4Å resolution

Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A804598

Released:
DOI: 10.2210/pdb5u1v/pdb
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PDB entry 5u1v coloured by chain, front view.
PDB entry 5u1v coloured by chain, side view.
PDB entry 5u1v coloured by chain, top view.
Source organism: Ailuropoda melanoleuca
Primary publication:
Structural basis for subtype-specific inhibition of the P2X7 receptor.
Karasawa A, Kawate T
OpenAccess logo Elife 5 (2016)
PMID: 27935479

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-124202 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
P2X purinoreceptor 7 intracellular domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 342 amino acids
Theoretical weight: 38.72 KDa
Source organism: Ailuropoda melanoleuca
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: G1M6C4 (Residues: 24-359; Coverage: 55%)
Gene name: P2RX7
Sequence domains: ATP P2X receptor
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand NAG 2 x NAG
Ligand 7S1 1 x 7S1
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CHESS BEAMLINE F1
Spacegroup: I213
Unit cell:
a: 170.403Å b: 170.403Å c: 170.403Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.253 0.25 0.272
Expression system: Spodoptera frugiperda

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Citations

47 review citations

The P2X7 Receptor in Infection and Inflammation.
Di Virgilio et al. (2017)
46 more

7 mentions without citation

Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology.
Oken et al. (2022)
6 more

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