› 5vb8

X-ray diffraction
2.85Å resolution

Crystal structure of the NavAb voltage-gated sodium channel in an open state

Released:
DOI: 10.2210/pdb5vb8/pdb
PDB entry 5vb8 coloured by chain, front view.
PDB entry 5vb8 coloured by chain, side view.
PDB entry 5vb8 coloured by chain, top view.
Source organism: Aliarcobacter butzleri
Primary publication:
Structures of closed and open states of a voltage-gated sodium channel.
Lenaeus MJ, Gamal El-Din TM, Ing C, Ramanadane K, Pomès R, Zheng N, Catterall WA
Proc Natl Acad Sci U S A 114 E3051-E3060 (2017)
PMID: 28348242

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-501454 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 28.2 KDa
Source organism: Aliarcobacter butzleri
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A8EVM5 (Residues: 1-226; Coverage: 85%)
Gene name: Abu_1752
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NA 1 x NA
Ligand PX4 4 x PX4
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: I422
Unit cell:
a: 125.302Å b: 125.302Å c: 192.424Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.23 0.228 0.254
Expression system: Trichoplusia ni

Quick links

Citations

16 review citations

Emerging Diversity in Lipid-Protein Interactions.
Corradi et al. (2019)
15 more

17 mentions without citation

De novo CACNA1D Ca2+ channelopathies: clinical phenotypes and molecular mechanism.
Ortner et al. (2020)
16 more