5vh5

X-ray diffraction
1.75Å resolution

Crystal Structure of Fc fragment of anti-TNFa antibody infliximab

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-166208 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Infliximab Fc Chain: A
Molecule details ›
Chain: A
Length: 255 amino acids
Theoretical weight: 28.36 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN, GAL, FUL
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: C2221
Unit cell:
a: 50.16Å b: 148.03Å c: 75.9Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.19 0.228
Expression system: Cricetulus griseus