› 7b16

Electron Microscopy
3.15Å resolution

TRPC4 in complex with inhibitor GFB-9289

Released:
DOI: 10.2210/pdb7b16/pdb
PDB entry 7b16 coloured by chain, front view.
PDB entry 7b16 coloured by chain, side view.
PDB entry 7b16 coloured by chain, top view.
Source organism: Danio rerio
Primary publication:
Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
OpenAccess logo Elife 9 (2020)
PMID: 33236980
Related structures: EMD-11979

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-197547 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor ion channel domain-containing protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 915 amino acids
Theoretical weight: 105.2 KDa
Source organism: Danio rerio
Expression system: Homo sapiens
UniProt:
  • Canonical: U3N7D8 (Residues: 2-915; Coverage: 100%)
Gene names: trpc4a, trpc4b
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand SKQ 4 x SKQ
Ligand CA 4 x CA
Ligand LPP 4 x LPP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.15Å
Relevant EMDB volumes: EMD-11979
Expression system: Homo sapiens

Quick links

Citations

9 review citations

TRP (transient receptor potential) ion channel family: structures, biological functions and therapeutic interventions for diseases.
Zhang et al. (2023)
8 more

2 mentions without citation

Structural Pharmacology of TRP Channels.
Zhao et al. (2021)
1 more