› 7d99

Electron Microscopy
2.9Å resolution

human potassium-chloride co-transporter KCC4

Released:
DOI: 10.2210/pdb7d99/pdb
PDB entry 7d99 coloured by chain, front view.
PDB entry 7d99 coloured by chain, side view.
PDB entry 7d99 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures and an activation mechanism of human potassium-chloride cotransporters.
Xie Y, Chang S, Zhao C, Wang F, Liu S, Wang J, Delpire E, Ye S, Guo J
OpenAccess logo Sci Adv 6 (2020)
PMID: 33310850
Related structures: EMD-30617

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-195339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 12 member 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 1113 amino acids
Theoretical weight: 123.07 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9Y666 (Residues: 1-1083; Coverage: 100%)
Gene names: KCC4, SLC12A7
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
2 bound ligands:
Ligand K 2 x K
Ligand CL 4 x CL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 2.9Å
Relevant EMDB volumes: EMD-30617
Expression system: Homo sapiens

Quick links

Citations

11 review citations

NKCC1: Newly Found as a Human Disease-Causing Ion Transporter.
Koumangoye et al. (2021)
10 more

7 mentions without citation

High-Resolution Views and Transport Mechanisms of the NKCC1 and KCC Transporters.
Chew et al. (2021)
6 more