› 7l6q

Electron Microscopy
2.5Å resolution

Unliganded ELIC in styrene-maleic-acid nanodiscs at 2.5-Angstrom resolution

Released:
DOI: 10.2210/pdb7l6q/pdb
PDB entry 7l6q coloured by chain, front view.
PDB entry 7l6q coloured by chain, side view.
PDB entry 7l6q coloured by chain, top view.
Source organism: Dickeya dadantii 3937
Primary publication:
Structure and function at the lipid-protein interface of a pentameric ligand-gated ion channel.
Kumar P, Cymes GD, Grosman C
Proc Natl Acad Sci U S A 118 (2021)
PMID: 34083441
Related structures: EMD-23207

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo pentamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-122692 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neurotransmitter-gated ion-channel ligand-binding domain-containing protein Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 322 amino acids
Theoretical weight: 36.88 KDa
Source organism: Dickeya dadantii 3937
Expression system: Escherichia coli
UniProt:
  • Canonical: E0SJQ4 (Residues: 22-343; Coverage: 100%)
Gene name: Dda3937_00520
Sequence domains: Neurotransmitter-gated ion-channel ligand binding domain

Ligands and Environments

2 bound ligands:
Ligand PGW 5 x PGW
Ligand CDL 5 x CDL
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.5Å
Relevant EMDB volumes: EMD-23207
Expression system: Escherichia coli

Quick links

Citations

3 review citations

Pursuing High-Resolution Structures of Nicotinic Acetylcholine Receptors: Lessons Learned from Five Decades.
Delgado-Vélez et al. (2021)
2 more

5 mentions without citation

Druggable Lipid Binding Sites in Pentameric Ligand-Gated Ion Channels and Transient Receptor Potential Channels.
Cheng et al. (2021)
4 more