› 7lr0

Electron Microscopy
3.81Å resolution

Structure of squirrel TRPV1 in complex with capsaicin

Released:
DOI: 10.2210/pdb7lr0/pdb
PDB entry 7lr0 coloured by chain, front view.
PDB entry 7lr0 coloured by chain, side view.
PDB entry 7lr0 coloured by chain, top view.
Source organism: Ictidomys tridecemlineatus
Primary publication:
Extracellular cap domain is an essential component of the TRPV1 gating mechanism.
Nadezhdin KD, Neuberger A, Nikolaev YA, Murphy LA, Gracheva EO, Bagriantsev SN, Sobolevsky AI
OpenAccess logo Nat Commun 12 2154 (2021)
PMID: 33846324
Related structures: EMD-23493

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-125076 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 844 amino acids
Theoretical weight: 95.9 KDa
Source organism: Ictidomys tridecemlineatus
Expression system: Homo sapiens
UniProt:
  • Canonical: I3LZN5 (Residues: 1-840; Coverage: 100%)
Gene name: TRPV1
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand POV 28 x POV
Ligand 4DY 4 x 4DY
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.81Å
Relevant EMDB volumes: EMD-23493
Expression system: Homo sapiens

Quick links

Citations

3 review citations

TRP channels: a journey towards a molecular understanding of pain.
Rosenbaum et al. (2022)
2 more

7 mentions without citation

Ligand-Binding Sites in Vanilloid-Subtype TRP Channels.
Yelshanskaya et al. (2022)
6 more