› 7x6c

Electron Microscopy
3.15Å resolution

Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1

Released:
DOI: 10.2210/pdb7x6c/pdb
PDB entry 7x6c coloured by chain, front view.
PDB entry 7x6c coloured by chain, side view.
PDB entry 7x6c coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular architecture of the Gαi-bound TRPC5 ion channel.
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
OpenAccess logo Nat Commun 14 2550 (2023)
PMID: 37137991
Related structures: EMD-33021

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193913 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Short transient receptor potential channel 5 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 773 amino acids
Theoretical weight: 89.95 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: Q9UL62 (Residues: 1-765; Coverage: 79%)
Gene names: TRP5, TRPC5
Sequence domains:

Ligands and Environments

6 bound ligands:
Ligand PTY 4 x PTY
Ligand POV 4 x POV
Ligand Y01 4 x Y01
Ligand ZN 4 x ZN
Ligand CA 4 x CA
Ligand YZY 4 x YZY
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.15Å
Relevant EMDB volumes: EMD-33021
Expression system: Homo sapiens

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Citations

1 review citation

Direct modulation of TRPC ion channels by Gα proteins.
Kang et al. (2024)
5 other articles