Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Serine protease/helicase NS3 (preferred)
PDBe Complex ID:
PDB-CPX-150815 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine protease/helicase NS3
Molecule details ›
Chain: A
Length: 435 amino acids
Theoretical weight: 46.6 KDa
Source organism: Hepacivirus hominis
Expression system: Escherichia coli BL21(DE3)
UniProt:
Structure domains:
Length: 435 amino acids
Theoretical weight: 46.6 KDa
Source organism: Hepacivirus hominis
Expression system: Escherichia coli BL21(DE3)
UniProt:
- Canonical:
P26663 (Residues: 1216-1650; Coverage: 15%)
Structure domains:
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
MACSCIENCE M18X
Spacegroup:
P3121
Expression system: Escherichia coli BL21(DE3)
