› 199d

Solution NMR

Solution structure of the monoalkylated mitomycin c-DNA complex

Released:
DOI: 10.2210/pdb199d/pdb
PDB entry 199d coloured by chain, ensemble of 3 models, front view.
PDB entry 199d coloured by chain, ensemble of 3 models, side view.
PDB entry 199d coloured by chain, ensemble of 3 models, top view.
Source organism: Synthetic construct
Primary publication:
Solution structure of the monoalkylated mitomycin C-DNA complex.
Sastry M, Fiala R, Lipman R, Tomasz M, Patel DJ
J Mol Biol 247 338-59 (1995)
PMID: 7707379

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-113377 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
DNA (5'-D(*(DI)P*CP*AP*CP*GP*TP*CP*(DI)P*T)-3') Chain: A
Molecule details ›
Chain: A
Length: 9 nucleotides
Theoretical weight: 2.7 KDa
Source organism: Synthetic construct
Expression system: Not provided
DNA (5'-D(*AP*CP*GP*AP*CP*GP*TP*GP*C)-3') Chain: B
Molecule details ›
Chain: B
Length: 9 nucleotides
Theoretical weight: 2.74 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MOC 1 x MOC
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS, MATRIX RELAXATION
Expression system: Not provided

Quick links

Citations

5 review citations

Mitomycin C: small, fast and deadly (but very selective).
Tomasz M. (1995)
4 more

9 mentions without citation

Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.
Sheng et al. (2013)
8 more