› 1p9j

Solution NMR

Solution structure and dynamics of the EGF/TGF-alpha chimera T1E

Released:
DOI: 10.2210/pdb1p9j/pdb
PDB entry 1p9j coloured by chain, ensemble of 36 models, front view.
PDB entry 1p9j coloured by chain, ensemble of 36 models, side view.
PDB entry 1p9j coloured by chain, ensemble of 36 models, top view.
Source organism: Homo sapiens
Primary publication:
Structural analysis of an epidermal growth factor/transforming growth factor-alpha chimera with unique ErbB binding specificity.
Wingens M, Walma T, van Ingen H, Stortelers C, van Leeuwen JE, van Zoelen EJ, Vuister GW
J Biol Chem 278 39114-23 (2003)
PMID: 12869572

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134051 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Epidermal growth factor Chain: A
Molecule details ›
Chain: A
Length: 54 amino acids
Theoretical weight: 6.34 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P01133 (Residues: 974-1022; Coverage: 4%)
Gene name: EGF
Sequence domains: EGF-like domain
Structure domains: Laminin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 55%
Refinement method: distance geometry followed by brief molecular dynamics run in water.
Expression system: Komagataella pastoris

Quick links

Citations

3 review citations

Advances in the use of natural receptor- or ligand-based chimeric antigen receptors (CARs) in haematologic malignancies.
Murad et al. (2018)
2 more

1 mention without citation

Screening of differential gene expression patterns through survival analysis for diagnosis, prognosis and therapies of clear cell renal cell carcinoma.
Ajadee et al. (2024)