› 1qwt

X-ray diffraction
2.1Å resolution

Auto-inhibitory interferon regulation factor-3 (IRF3) transactivation domain

Released:
DOI: 10.2210/pdb1qwt/pdb
PDB entry 1qwt coloured by chain, front view.
PDB entry 1qwt coloured by chain, side view.
PDB entry 1qwt coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of IRF-3 reveals mechanism of autoinhibition and virus-induced phosphoactivation.
Qin BY, Liu C, Lam SS, Srinath H, Delston R, Correia JJ, Derynck R, Lin K
Nat Struct Biol 10 913-21 (2003)
PMID: 14555996

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-556485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Interferon regulatory factor 3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 255 amino acids
Theoretical weight: 28.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q14653 (Residues: 173-427; Coverage: 60%)
Gene name: IRF3
Sequence domains: Interferon-regulatory factor 3
Structure domains: Tumour Suppressor Smad4

Ligands and Environments

1 bound ligand:
Ligand PO4 8 x PO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.1
Spacegroup: P4212
Unit cell:
a: 135.545Å b: 135.545Å c: 68.521Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.195 0.214
Expression system: Escherichia coli

Quick links

Citations

36 review citations

Specificity and versatility in tgf-beta signaling through Smads.
Feng et al. (2005)
35 more

14 mentions without citation

Therapeutic Targeting of IRFs: Pathway-Dependence or Structure-Based?
Thompson et al. (2018)
13 more