› 1vfl

X-ray diffraction
1.8Å resolution

Adenosine deaminase

Released:
DOI: 10.2210/pdb1vfl/pdb
PDB entry 1vfl coloured by chain, front view.
PDB entry 1vfl coloured by chain, side view.
PDB entry 1vfl coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
Structural basis of compound recognition by adenosine deaminase.
Kinoshita T, Nakanishi I, Terasaka T, Kuno M, Seki N, Warizaya M, Matsumura H, Inoue T, Takano K, Adachi H, Mori Y, Fujii T
Biochemistry 44 10562-9 (2005)
PMID: 16060665

Function and Biology Details

Reaction catalysed: 
2'-deoxyadenosine + H(2)O = 2'-deoxyinosine + NH(3)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157515 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosine deaminase Chain: A
Molecule details ›
Chain: A
Length: 356 amino acids
Theoretical weight: 40.34 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: P56658 (Residues: 2-357; Coverage: 98%)
Gene name: ADA
Sequence domains: Adenosine deaminase
Structure domains: Metal-dependent hydrolases

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: P43212
Unit cell:
a: 73.726Å b: 73.726Å c: 134.013Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.23 0.267

Quick links

Citations

2 review citations

Moonlighting adenosine deaminase: a target protein for drug development.
Cortés et al. (2015)
1 more

8 mentions without citation

Targeting Metalloenzymes for Therapeutic Intervention.
Chen et al. (2019)
7 more