› 1dir

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF A MONOCLINIC FORM OF DIHYDROPTERIDINE REDUCTASE FROM RAT LIVER

Released:
DOI: 10.2210/pdb1dir/pdb
PDB entry 1dir coloured by chain, front view.
PDB entry 1dir coloured by chain, side view.
PDB entry 1dir coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of a monoclinic form of dihydropteridine reductase from rat liver.
Su Y, Skinner MM, Xuong NH, Matthews DA, Whiteley JM, Varughese KI
Acta Crystallogr D Biol Crystallogr 50 884-8 (1994)
PMID: 15299357

Function and Biology Details

Reaction catalysed: 
A 5,6,7,8-tetrahydropteridine + NAD(P)(+) = a 6,7-dihydropteridine + NAD(P)H
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo tetramer
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145797 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dihydropteridine reductase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 241 amino acids
Theoretical weight: 25.58 KDa
Source organism: Rattus norvegicus
Expression system: Not provided
UniProt:
  • Canonical: P11348 (Residues: 1-241; Coverage: 100%)
Gene names: Dhpr, Qdpr
Sequence domains: short chain dehydrogenase
Structure domains: NAD(P)-binding Rossmann-like Domain

Ligands and Environments


Cofactor: Ligand NAD 4 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: C2
Unit cell:
a: 222.2Å b: 46.5Å c: 94.3Å
α: 90° β: 101.1° γ: 90°
R-values:
R R work R free
0.168 0.168 not available
Expression system: Not provided

Quick links

Citations

1 citations in other articles

Structural genomics of Caenorhabditis elegans: structure of dihydropteridine reductase.
Symersky et al. (2003)

1 mention without citation

Weber Texture Local Descriptor for Identification of Group-Housed Pigs.
Huang et al. (2020)