› 1jsv

X-ray diffraction
1.96Å resolution

The structure of cyclin-dependent kinase 2 (CDK2) in complex with 4-[(6-amino-4-pyrimidinyl)amino]benzenesulfonamide

Released:
DOI: 10.2210/pdb1jsv/pdb
PDB entry 1jsv coloured by chain, front view.
PDB entry 1jsv coloured by chain, side view.
PDB entry 1jsv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The cyclin-dependent kinases cdk2 and cdk5 act by a random, anticooperative kinetic mechanism.
Clare PM, Poorman RA, Kelley LC, Watenpaugh KD, Bannow CA, Leach KL
J Biol Chem 276 48292-9 (2001)
PMID: 11604388

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150313 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 298 amino acids
Theoretical weight: 33.98 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P24941 (Residues: 1-298; Coverage: 100%)
Gene names: CDK2, CDKN2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand U55 1 x U55
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P212121
Unit cell:
a: 54.032Å b: 72.058Å c: 72.197Å
α: 90° β: 90° γ: 90°
Expression system: Spodoptera frugiperda

Quick links

Citations

3 review citations

Pharmacological inhibitors of cyclin-dependent kinases.
Knockaert et al. (2002)
2 more

8 mentions without citation

Toward the estimation of the absolute quality of individual protein structure models.
Benkert et al. (2011)
7 more