› 1lo3

X-ray diffraction
2.3Å resolution

Retro-Diels-Alderase Catalytic Antibody: Product Analogue

Released:
DOI: 10.2210/pdb1lo3/pdb
PDB entry 1lo3 coloured by chain, front view.
PDB entry 1lo3 coloured by chain, side view.
PDB entry 1lo3 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Hugot M, Bensel N, Vogel M, Reymond MT, Stadler B, Reymond JL, Baumann U
Proc Natl Acad Sci U S A 99 9674-8 (2002)
PMID: 12093912

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179239 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chains: L, X
Molecule details ›
Chains: L, X
Length: 219 amino acids
Theoretical weight: 24.27 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q65ZC0 (Residues: 1-219; Coverage: 100%)
Sequence domains:
Structure domains: Immunoglobulins
Ig-like domain-containing protein Chains: H, Y
Molecule details ›
Chains: H, Y
Length: 220 amino acids
Theoretical weight: 23.7 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: Q91Z05 (Residues: 20-117, 118-239; Coverage: 48%)
Gene names: AU044919, Ighg
Sequence domains:
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand AN1 2 x AN1
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P21
Unit cell:
a: 40.384Å b: 139.768Å c: 84.86Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.208 0.259

Quick links

Citations

4 review citations

Computational enzyme design.
Kiss et al. (2013)
3 more

1 mention without citation

A structural basis for the activity of retro-Diels-Alder catalytic antibodies: evidence for a catalytic aromatic residue.
Hugot et al. (2002)