› 1mwl

X-ray diffraction
2.4Å resolution

Crystal structure of geneticin bound to the eubacterial 16S rRNA A site

Released:
DOI: 10.2210/pdb1mwl/pdb
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PDB entry 1mwl coloured by chain, front view.
PDB entry 1mwl coloured by chain, side view.
PDB entry 1mwl coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Crystal structure of geneticin bound to a bacterial 16S ribosomal RNA A site oligonucleotide.
Vicens Q, Westhof E
J Mol Biol 326 1175-88 (2003)
PMID: 12589761

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196131 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
5'-R(*CP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 22 nucleotides
Theoretical weight: 7.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand GET 2 x GET
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ESRF BEAMLINE ID14-4, ESRF BEAMLINE ID14-1
Spacegroup: P21
Unit cell:
a: 46.2Å b: 33.18Å c: 51.74Å
α: 90° β: 104.13° γ: 90°
R-values:
R R work R free
0.224 0.224 0.249
Expression system: Not provided

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Citations

17 review citations

The bacterial ribosome as a target for antibiotics.
Poehlsgaard et al. (2005)
16 more

16 mentions without citation

Recent Advances in Exploration and Biotechnological Production of Bioactive Compounds in Three Cyanobacterial Genera: Nostoc, Lyngbya, and Microcystis.
Thuan et al. (2019)
15 more

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