Function and Biology Details
Reactions catalysed:
Precorrin-2 + NAD(+) = sirohydrochlorin + NADH
(1a) S-adenosyl-L-methionine + uroporphyrinogen III = S-adenosyl-L-homocysteine + precorrin-1
Siroheme + 2 H(+) = sirohydrochlorin + Fe(2+)
Sequence domains:
- Uroporphyrin-III C-methyltransferase
- Uroporphiryn-III C-methyltransferase, conserved site
- Tetrapyrrole methylase, subdomain 2
- Tetrapyrrole methylase
- Tetrapyrrole methylase superfamily
- Tetrapyrrole methylase, subdomain 1
- Sirohaem synthase, dimerisation domain
- Sirohaem synthase, dimerisation domain superfamily
4 more domains
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Siroheme synthase (preferred)
PDBe Complex ID:
PDB-CPX-150613 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule: