› 1s95

X-ray diffraction
1.6Å resolution

Structure of serine/threonine protein phosphatase 5

Released:
DOI: 10.2210/pdb1s95/pdb
PDB entry 1s95 coloured by chain, front view.
PDB entry 1s95 coloured by chain, side view.
PDB entry 1s95 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the catalytic activity of human serine/threonine protein phosphatase-5.
Swingle MR, Honkanen RE, Ciszak EM
J Biol Chem 279 33992-9 (2004)
PMID: 15155720

Function and Biology Details

Reaction catalysed: 
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-156702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein phosphatase 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 37.89 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P53041 (Residues: 169-499; Coverage: 66%)
Gene names: PPP5, PPP5C
Sequence domains:
Structure domains: Purple Acid Phosphatase; chain A, domain 2

Ligands and Environments

3 bound ligands:
Ligand MN 4 x MN
Ligand PO4 2 x PO4
Ligand MPD 2 x MPD
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 40.808Å b: 80.309Å c: 92.189Å
α: 90° β: 94.25° γ: 90°
R-values:
R R work R free
0.171 0.169 0.209
Expression system: Escherichia coli BL21

Quick links

Citations

9 review citations

Protein serine/threonine phosphatases: life, death, and sleeping.
Gallego et al. (2005)
8 more

18 mentions without citation

The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancer.
Golden et al. (2008)
17 more