Function and Biology Details
Reaction catalysed:
Hydrolysis of -Gln(76)-|-Phe- bond in synaptobrevin (also known as neuronal vesicle-associated membrane protein, VAMP).
Biochemical function:
- not assigned
Biological process:
- not assigned
Cellular component:
Sequence domains:
Structure analysis Details
Assembly composition:
monomeric (preferred)
Assembly name:
Tetanus toxin heavy chain (preferred)
PDBe Complex ID:
PDB-CPX-138291 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Tetanus toxin heavy chain
Molecule details ›
Chain: A
Length: 441 amino acids
Theoretical weight: 50.48 KDa
Source organism: Clostridium tetani
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 441 amino acids
Theoretical weight: 50.48 KDa
Source organism: Clostridium tetani
Expression system: Escherichia coli
UniProt:
- Canonical:
P04958 (Residues: 875-1315; Coverage: 34%)
Sequence domains:
- Clostridium neurotoxin, N-terminal receptor binding
- Clostridium neurotoxin, C-terminal receptor binding
Ligands and Environments
Experiments and Validation Details
X-ray source:
NSLS BEAMLINE X12C
Spacegroup:
P212121
Expression system: Escherichia coli
