› 2g57

Solution NMR

Structure of the Phosphorylation Motif of the oncogenic Protein beta-Catenin Recognized By a Selective Monoclonal Antibody

Released:
DOI: 10.2210/pdb2g57/pdb
PDB entry 2g57 coloured by chain, ensemble of 10 models, front view.
PDB entry 2g57 coloured by chain, ensemble of 10 models, side view.
PDB entry 2g57 coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
STD and TRNOESY NMR studies for the epitope mapping of the phosphorylation motif of the oncogenic protein beta-catenin recognized by a selective monoclonal antibody.
Megy S, Bertho G, Gharbi-Benarous J, Baleux F, Benarous R, Girault JP
FEBS Lett 580 5411-22 (2006)
PMID: 16996060

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-555546 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin beta-1 Chain: A
Molecule details ›
Chain: A
Length: 28 amino acids
Theoretical weight: 2.93 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q0PNE9 (Residues: 15-40; Coverage: 5%)

Ligands and Environments

No bound ligands
1 modified residue:
Ligand SEP 2 x SEP

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry, simulated annealing, torsion angle dynamics
Expression system: Not provided

Quick links

Citations

3 citation in other articles

GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
Oh et al. (2009)
2 more

2 mentions without citation

Human germline and pan-cancer variomes and their distinct functional profiles.
Pan et al. (2014)
1 more