2xwt

X-ray diffraction
1.9Å resolution

CRYSTAL STRUCTURE OF THE TSH RECEPTOR IN COMPLEX WITH A BLOCKING TYPE TSHR AUTOANTIBODY

Released:
Model geometry
Fit model/data

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-210697 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 HEAVY CHAIN Chain: A
Molecule details ›
Chain: A
Length: 221 amino acids
Theoretical weight: 23.64 KDa
Source organism: Homo sapiens
Expression system: hybrid
Structure domains: Immunoglobulins
THYROID BLOCKING HUMAN AUTOANTIBODY K1-70 LIGHT CHAIN Chain: B
Molecule details ›
Chain: B
Length: 214 amino acids
Theoretical weight: 22.6 KDa
Source organism: Homo sapiens
Expression system: hybrid
Structure domains: Immunoglobulins
Thyrotropin receptor Chain: C

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P212121
Unit cell:
a: 83.02Å b: 89.3Å c: 101.27Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.179 0.177 0.227
Expression systems:
  • hybrid
  • Trichoplusia ni