› 2y02

X-ray diffraction
2.6Å resolution

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND AGONIST CARMOTEROL

Released:
DOI: 10.2210/pdb2y02/pdb
PDB entry 2y02 coloured by chain, front view.
PDB entry 2y02 coloured by chain, side view.
PDB entry 2y02 coloured by chain, top view.
Source organism: Meleagris gallopavo
Primary publication:
The structural basis for agonist and partial agonist action on a β(1)-adrenergic receptor.
Warne T, Moukhametzianov R, Baker JG, Nehmé R, Edwards PC, Leslie AG, Schertler GF, Tate CG
OpenAccess logo Nature 469 241-4 (2011)
PMID: 21228877

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-139703 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-1 adrenergic receptor Chains: A, B
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 35.94 KDa
Source organism: Meleagris gallopavo
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P07700 (Residues: 33-368; Coverage: 64%)
Gene name: ADRB1
Sequence domains: 7 transmembrane receptor (rhodopsin family)
Structure domains: Rhodopsin 7-helix transmembrane proteins

Ligands and Environments

4 bound ligands:
Ligand Y01 4 x Y01
Ligand 2CV 10 x 2CV
Ligand WHJ 2 x WHJ
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-2
Spacegroup: P21
Unit cell:
a: 89.6Å b: 61.7Å c: 101.4Å
α: 90° β: 109.3° γ: 90°
R-values:
R R work R free
0.231 0.229 0.268
Expression system: Trichoplusia ni

Quick links

Citations

78 review citations

Molecular signatures of G-protein-coupled receptors.
Venkatakrishnan et al. (2013)
77 more

37 mentions without citation

Structure-function of the G protein-coupled receptor superfamily.
Katritch et al. (2013)
36 more