Function and Biology Details
Reaction catalysed:
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
alpha-thrombin complex (preferred)
PDBe Complex ID:
PDB-CPX-133055 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Activation peptide fragment 2
Molecule details ›
Chain: L
Length: 158 amino acids
Theoretical weight: 17.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains:
Structure domains:
Length: 158 amino acids
Theoretical weight: 17.59 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical:
P00734 (Residues: 206-363; Coverage: 26%)
Sequence domains:
Structure domains:
Thrombin heavy chain
Molecule details ›
Chain: H
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Length: 259 amino acids
Theoretical weight: 29.78 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
- Canonical: P00734 (Residues: 364-622; Coverage: 43%)
Sequence domains: Trypsin
Structure domains: Trypsin-like serine proteases
Ligands and Environments
Experiments and Validation Details
wwPDB Validation report is not available for this entry.
X-ray source:
APS BEAMLINE 14-BM-C
Spacegroup:
P41212
Expression system: Cricetulus griseus
