› 3nmw

X-ray diffraction
1.6Å resolution

Crystal structure of armadillo repeats domain of APC

Released:
DOI: 10.2210/pdb3nmw/pdb
PDB entry 3nmw coloured by chain, front view.
PDB entry 3nmw coloured by chain, side view.
PDB entry 3nmw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of Asef by adenomatous polyposis coli.
Zhang Z, Chen L, Gao L, Lin K, Zhu L, Lu Y, Shi X, Gao Y, Zhou J, Xu P, Zhang J, Wu G
Cell Res 22 372-86 (2012)
PMID: 21788986

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150339 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenomatous polyposis coli protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 354 amino acids
Theoretical weight: 40.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P25054 (Residues: 407-751; Coverage: 12%)
Gene names: APC, DP2.5
Sequence domains:
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

1 bound ligand:
Ligand SO4 2 x SO4
1 modified residue:
Ligand MSE 34 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 51.389Å b: 52.682Å c: 63.451Å
α: 90.31° β: 89.95° γ: 95.16°
R-values:
R R work R free
0.17 0.168 0.201
Expression system: Escherichia coli

Quick links

Citations

3 review citations

The emerging role of guanine nucleotide exchange factors in ALS and other neurodegenerative diseases.
Droppelmann et al. (2014)
2 more

7 mentions without citation

Advances and Insights of APC-Asef Inhibitors for Metastatic Colorectal Cancer Therapy.
Yang et al. (2021)
6 more