› 3r2w

X-ray diffraction
3.6Å resolution

Crystal Structure of UDP-glucose Pyrophosphorylase of Homo Sapiens

Released:
DOI: 10.2210/pdb3r2w/pdb
Model geometry
Fit model/data
PDB entry 3r2w coloured by chain, front view.
PDB entry 3r2w coloured by chain, side view.
PDB entry 3r2w coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The crystal structure of human UDP-glucose pyrophosphorylase reveals a latch effect that influences enzymatic activity.
Yu Q, Zheng X
Biochem J 442 283-91 (2012)
PMID: 22132858

Function and Biology Details

Reaction catalysed: 
UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
UTP--glucose-1-phosphate uridylyltransferase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 528 amino acids
Theoretical weight: 59.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16851 (Residues: 1-508; Coverage: 100%)
Gene names: UGP1, UGP2
Sequence domains: UTP--glucose-1-phosphate uridylyltransferase
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P3121
Unit cell:
a: 140.445Å b: 140.445Å c: 311.724Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.25 0.248 0.304
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Glycogen metabolism in humans.
Adeva-Andany et al. (2016)
3 more

3 mentions without citation

A quaternary mechanism enables the complex biological functions of octameric human UDP-glucose pyrophosphorylase, a key enzyme in cell metabolism.
Führing et al. (2015)
2 more